Overview

  • Product name

    Fluocinolone acetonide, Corticosteroid
  • Description

    Potent synthetic corticosteroid
  • Biological description

    Potent synthetic corticosteroid (EC50 = 2 nM at glucocorticoid receptor). Inhibits VEGF secretion and expression. Inhibits proliferation and TNF-α-induced angiogenesis. Shows anti-inflammatory and neuroprotective effects in vivo.
  • Purity

    > 98%
  • CAS Number

    67-73-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
  • Molecular weight

    452.49
  • Molecular formula

    C24H30F2O6
  • PubChem identifier

    3381
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)F)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Glybina IV  et al. Intravitreous delivery of the corticosteroid fluocinolone acetonide attenuates retinal degeneration in S334ter-4 rats. Invest Ophthalmol Vis Sci 51:4243-52 (2010). Read more (PubMed: 20220055) »
  • Ayalasomayajula SP  et al. Fluocinolone inhibits VEGF expression via glucocorticoid receptor in human retinal pigment epithelial (ARPE-19) cells and TNF-alpha-induced angiogenesis in chick chorioallantoic membrane (CAM). J Ocul Pharmacol Ther 25:97-103 (2009). Read more (PubMed: 19284324) »
  • Nehmé A  et al. Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics 2:58 (2009). Read more (PubMed: 19744340) »

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