Overview

  • Product name

    Fluphenazine hydrochloride, dopamine D2/D1 receptor antagonist
  • Description

    Potent dopamine D2/D1 receptor antagonist
  • Biological description

    Potent dopamine D2/D1 receptor antagonist (Ki values are 0.4 (D2), 2.3 (D1), 1.4 (D3), 7.1 (D4) and 25 nM (D5)). Inhibits dopamine-induced increases in adenylate cyclase activity (Ki = 9 nM). Antipsychotic. Active in vivo.
  • Purity

    > 97%
  • CAS Number

    146-56-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Burstein ES  et al. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. J Pharmacol Exp Ther 315:1278-87 (2005). Read more (PubMed: 16135699) »
  • Martin MW  et al. Typical antipsychotics exhibit inverse agonist activity at rat dopamine D1-like receptors expressed in Sf9 cells. Eur J Pharmacol 420:73-82 (2001). Read more (PubMed: 11408027) »
  • Cai G  et al. Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein. Mol Pharmacol 56:989-96 (1999). Read more (PubMed: 10531405) »
  • Prémont J  et al. Repartition and drug sensitivity of dopamine and L-isoproterenol-sensitive adenylate cyclases in rat brain homogenates. Adv Biochem Psychopharmacol 15:347-56 (1976). Read more (PubMed: 192054) »

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