Overview

  • Product name

    Flupirtine maleate, Neuronal potassium channel opener
  • Description

    Neuronal potassium channel opener
  • Biological description

    Neuronal potassium channel opener. Activates Kv7.2 channels and potently activates the inwardly rectifying potassium current (KIR; EC50 = 600 nM). Centrally acting, non-opiate analgesic. Neuroprotective and antiapoptotic agent. Also has muscle relaxant properties. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    75507-68-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate maleate
  • Molecular weight

    420.40
  • Molecular formula

    C15H17FN4O2.C4H4O4
  • PubChem identifier

    6435335
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCOC(=O)NC1=C(N=C(C=C1)NCC2=CC=C(C=C2)F)N.C(=CC(=O)O)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Morecroft I  et al. Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. Br J Pharmacol 157:1241-9 (2009). Read more (PubMed: 19508393) »
  • Kornhuber J  et al. [Neuronal potassium channel opening with flupirtine]. Fortschr Neurol Psychiatr 67:466-75 (1999). Read more (PubMed: 10596368) »
  • Rupalla K  et al. Flupirtine protects neurons against excitotoxic or ischemic damage and inhibits the increase in cytosolic Ca2+ concentration. Eur J Pharmacol 294:469-73 (1995). Read more (PubMed: 8750707) »
  • Perovic S  et al. The triaminopyridine flupirtine prevents cell death in rat cortical cells induced by N-methyl-D-aspartate and gp120 of HIV-1. Eur J Pharmacol 288:27-33 (1994). Read more (PubMed: 7705465) »
  • Szelenyi I  et al. Mode of antinociceptive action of flupirtine in the rat. Br J Pharmacol 97:835-42 (1989). Read more (PubMed: 2569346) »

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