Overview

  • Product name

    Flurbiprofen, COX inhibitor NSAID
  • Description

    Potent COX inhibitor. NSAID.
  • Biological description

    Potent COX inhibitor (IC50 values are 0.1 and 0.4 μM for COX-1 and COX-2 respectively). NSAID. Shows analgesic, anti-inflammatory and antipyretic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    5104-49-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(3-Fluoro-4-phenylphenyl)propanoic acid
  • Molecular weight

    244.26
  • Molecular formula

    C15H13FO2
  • PubChem identifier

    3394
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Fu H  et al. Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3ß signaling and mitochondrial permeability transition. Mol Med 18:1128-35 (2012). Read more (PubMed: 22714712) »
  • Lumholdt LR  et al. In vitro investigations of a-amylase mediated hydrolysis of cyclodextrins in the presence of ibuprofen, flurbiprofen, or benzo[a]pyrene. Carbohydr Res 362:56-61 (2012). Read more (PubMed: 23085220) »
  • Glenn EM  et al. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions 3:210-6 (1973). Read more (PubMed: 4776365) »

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