Overview

  • Product name

    Flutamide, Androgen receptor antagonist
  • Description

    Non-steroidal, competitive androgen receptor antagonist
  • Alternative names

    • FLUT
  • Biological description

    Non-steroidal, competitive androgen receptor antagonist. Limits the uptake of testosterone by the prostate.
  • Purity

    > 99%
  • CAS Number

    13311-84-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
  • Molecular weight

    276.21
  • Molecular formula

    C11H11F3N2O3
  • PubChem identifier

    3397
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(Nc1cc(c(cc1)[N+]([O-])=O)C(F)(F)F)C(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Anahara R  et al. Review of the histological effects of the anti-androgen, flutamide, on mouse testis. Reprod Toxicol 25:139-43 (2008). Read more (PubMed: 18243649) »
  • Labrie F Mechanism of action and pure antiandrogenic properties of flutamide. Cancer 72:3816-27 (1993). Read more (PubMed: 8252497) »
  • Brogden RN & Chrisp P Flutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in advanced prostatic cancer. Drugs Aging 1:104-15 (1991). Read more (PubMed: 1794008) »

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