• Product name
  • Description
    Rabbit polyclonal to FLVCR
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 223-272 (GPKEVSTACA TAVLGNQLGT AVGFLLPPVL VPALGTQNST GLLAHTQNNT) of Mouse FLVCR (NP_001074728).

  • Positive control
    • Mouse brain lysate.



Our Abpromise guarantee covers the use of ab115865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro.
  • Tissue specificity
    Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.
  • Involvement in disease
    Defects in FLVCR1 are the cause of posterior column ataxia with retinitis pigmentosa (PCARP) [MIM:609033]. A neurodegenerative syndrome beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have no clinical or radiological evidence of cerebral or cerebellar involvement. Note=Defective neuronal heme transmembrane export due to FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the posterior spinal cord.
  • Sequence similarities
    Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
  • Developmental stage
    Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Feline leukemia virus subgroup C cellular receptor antibody
    • Feline leukemia virus subgroup C receptor antibody
    • Feline leukemia virus subgroup C receptor related protein 1 antibody
    • Feline leukemia virus subgroup C receptor-related protein 1 antibody
    • FLVC1_HUMAN antibody
    • FLVCR 1 antibody
    • FLVCR protein antibody
    • FLVCR1 antibody
    • hFLVCR antibody
    see all


  • Anti-FLVCR antibody (ab115865) at 1 µg/ml + Mouse brain lysate at 10 µg

    Predicted band size: 60 kDa

    Gel concentration: 12%


ab115865 has not yet been referenced specifically in any publications.

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