Overview

  • Product name

    Anti-FMN2 antibody - C-terminal
    See all FMN2 primary antibodies
  • Description

    Rabbit polyclonal to FMN2 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human FMN2 (C terminal). The exact sequence is proprietary.
    Database link: Q9NZ56

  • Positive control

    • WB: K562 and THP-1 whole cell extracts; human brain tissue extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab226944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 180 kDa.

Target

  • Function

    Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation.
  • Tissue specificity

    Expressed almost exclusively in the developing and mature central nervous system.
  • Sequence similarities

    Belongs to the formin homology family. Cappuccino subfamily.
    Contains 1 FH1 (formin homology 1) domain.
    Contains 1 FH2 (formin homology 2) domain.
  • Cellular localization

    Cytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Cytoplasm > cytosol. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasm > cell cortex. Nucleus > nucleolus. Recruited to the membranes via its interaction with SPIRE1. Colocalizes with the actin cytoskeleton. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.
  • Information by UniProt
  • Database links

  • Alternative names

    • FMN 2 antibody
    • Fmn2 antibody
    • FMN2_HUMAN antibody
    • Formin 2 antibody
    • Formin-2 antibody
    see all

Images

  • All lanes : Anti-FMN2 antibody - C-terminal (ab226944) at 1/1000 dilution

    Lane 1 : K562 (human chronic myelogenous leukemia cell line from bone marrow) whole cell extract
    Lane 2 : THP-1 (human monocytic leukemia cell line) whole cell extract
    Lane 3 : HL-60 (human promyelocytic leukemia cell line) whole cell extract
    Lane 4 : Human brain extract

    Lysates/proteins at 30 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 180 kDa

References

ab226944 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab226944.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up