Product nameAnti-FMN2 antibody - C-terminal
See all FMN2 primary antibodies
DescriptionRabbit polyclonal to FMN2 - C-terminal
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Recombinant fragment within Human FMN2 (C terminal). The exact sequence is proprietary.
Database link: Q9NZ56
- WB: K562 and THP-1 whole cell extracts; human brain tissue extract.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.025% Proclin
Constituents: PBS, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab226944 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 180 kDa.|
FunctionRequired for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation.
Tissue specificityExpressed almost exclusively in the developing and mature central nervous system.
Sequence similaritiesBelongs to the formin homology family. Cappuccino subfamily.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.
Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Cytoplasm > cytosol. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasm > cell cortex. Nucleus > nucleolus. Recruited to the membranes via its interaction with SPIRE1. Colocalizes with the actin cytoskeleton. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.
- Information by UniProt
- FMN 2 antibody
- Fmn2 antibody
- FMN2_HUMAN antibody
All lanes : Anti-FMN2 antibody - C-terminal (ab226944) at 1/1000 dilution
Lane 1 : K562 (human chronic myelogenous leukemia cell line from bone marrow) whole cell extract
Lane 2 : THP-1 (human monocytic leukemia cell line) whole cell extract
Lane 3 : HL-60 (human promyelocytic leukemia cell line) whole cell extract
Lane 4 : Human brain extract
Lysates/proteins at 30 µg per lane.
Developed using the ECL technique.
Predicted band size: 180 kDa
ab226944 has not yet been referenced specifically in any publications.