• Product name

  • Description

    Goat polyclonal to FMRP
  • Host species

  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Xenopus laevis, Orangutan
  • Immunogen

    Synthetic peptide:


    , corresponding to C terminal amino acids 606-619 of human FMRP (NP_002015.1)

  • Positive control

    • KELLY cell lysate.



Our Abpromise guarantee covers the use of ab82144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1:128,000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 71 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
    • Tissue specificity

      Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells.
    • Involvement in disease

      Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:300624]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.
      Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:300623]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:300624]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.
      Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:311360]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
    • Sequence similarities

      Belongs to the FMR1 family.
      Contains 2 KH domains.
    • Post-translational

      Phosphorylated on several serine residues.
    • Cellular localization

      Cytoplasm. Nucleus > nucleolus.
    • Information by UniProt
    • Database links

    • Alternative names

      • FMR 1 antibody
      • Fmr1 antibody
      • Fmr1 gene antibody
      • FMR1_HUMAN antibody
      • FMRP antibody
      • Fragile X mental retardation 1 antibody
      • Fragile X mental retardation 1 protein antibody
      • Fragile X mental retardation protein 1 antibody
      • Fragile X mental retardation protein antibody
      • fragile X mental retardation syndrome-related protein 1 antibody
      • fragile X mental retardation, autosomal homolog 1 antibody
      • FRAXA antibody
      • fxr1 antibody
      • MGC87458 antibody
      • POF antibody
      • POF1 antibody
      • Protein FMR-1 antibody
      • Protein FMR1 antibody
      • wu:fb16f11 antibody
      • wu:fd18c10 antibody
      • zgc:66226 antibody
      see all


    • Anti-FMRP antibody (ab82144) at 0.1 µg/ml + KELLY cell lysate at 35 µg

      Developed using the ECL technique.

      Predicted band size: 71 kDa
      Observed band size: 80 kDa
      why is the actual band size different from the predicted?

      Exposure time: 1 hour

      The observed molecular weight corresponds to earlier findings in literature with different antibodies (Sittler et al, Hum Mol Genet. 1996 Jan;5(1):95-102; PMID: 8789445).


    ab82144 has not yet been referenced specifically in any publications.

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