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    fog1-antibody-ab84876.pdf

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Epigenetics and Nuclear Signaling Transcription Domain Families Zinc Finger
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Anti-FOG1 antibody (ab84876)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOG1 antibody (ab84876)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOG1 antibody (ab84876)

Key features and details

  • Rabbit polyclonal to FOG1
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-FOG1 antibody
    See all FOG1 primary antibodies
  • Description

    Rabbit polyclonal to FOG1
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IHC-P
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide corresponding to a region between residue 175 and 225 of human FOG1 (accession number: NP_722520.2)

  • Positive control

    • Human Controls: Breast Carcinoma, Hodgkins Lymphoma, Prostate Carcinoma
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 6.8
    Preservative: 0.09% Sodium azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    Purified using an epitope specific to FOG1 immobilized on solid support.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Epigenetics and Nuclear Signaling
    • Transcription
    • Domain Families
    • Zinc Finger
    • Neuroscience
    • Neurology process
    • Neurogenesis
    • Cardiovascular
    • Heart
    • Cardiogenesis
    • Transcription factors/regulators

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab84876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Human
All applications
Chimpanzee
Gorilla
Application Abreviews Notes
IHC-P
Notes
  • Application notes
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
    • Tissue specificity

      Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.
    • Sequence similarities

      Belongs to the FOG (Friend of GATA) family.
      Contains 4 C2H2-type zinc fingers.
      Contains 5 C2HC-type zinc fingers.
    • Domain

      The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.
    • Post-translational
      modifications

      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession Q8IX07 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 161882 Human
      • Omim: 601950 Human
      • SwissProt: Q8IX07 Human
      • Unigene: 632218 Human
      • Alternative names

        • FOG-1 antibody
        • FOG1_HUMAN antibody
        • Friend of GATA 1 antibody
        • Friend of GATA protein 1 antibody
        • Friend of GATA1 antibody
        • ZFPM1 antibody
        • Zinc finger protein antibody
        • Zinc finger protein 89A antibody
        • Zinc finger protein multitype 1 antibody
        • Zinc finger protein ZFPM1 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOG1 antibody (ab84876)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOG1 antibody (ab84876)
        Detection of Human FOG1 in formalin-fixed paraffin-embedded section of human Hodgkin's Lymphoma by Immunohistochemistry using ab84876 at a dilution of 1:250. Detection: DAB staining.
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOG1 antibody (ab84876)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOG1 antibody (ab84876)
        Detection of Human FOG1 in formalin-fixed paraffin-embedded section of human breast carcinoma by Immunohistochemistry using ab84876 at a dilution of 1:250. Detection: DAB staining.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab84876? Please let us know so that we can cite the reference in this datasheet.

      ab84876 has not yet been referenced specifically in any publications.

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