Key features and details
- Rabbit polyclonal to FOG1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FOG1 antibody
See all FOG1 primary antibodies
DescriptionRabbit polyclonal to FOG1
Tested Applications & Species
Application Species IHC-PHuman
Synthetic peptide corresponding to a region between residue 175 and 225 of human FOG1 (accession number: NP_722520.2)
- Human Controls: Breast Carcinoma, Hodgkins Lymphoma, Prostate Carcinoma
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPurified using an epitope specific to FOG1 immobilized on solid support.
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab84876 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
Likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionTranscription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
Tissue specificityMainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.
Sequence similaritiesBelongs to the FOG (Friend of GATA) family.
Contains 4 C2H2-type zinc fingers.
Contains 5 C2HC-type zinc fingers.
DomainThe CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
- Information by UniProt
- FOG-1 antibody
- FOG1_HUMAN antibody
- Friend of GATA 1 antibody
Detection of Human FOG1 in formalin-fixed paraffin-embedded section of human Hodgkin's Lymphoma by Immunohistochemistry using ab84876 at a dilution of 1:250. Detection: DAB staining.
Detection of Human FOG1 in formalin-fixed paraffin-embedded section of human breast carcinoma by Immunohistochemistry using ab84876 at a dilution of 1:250. Detection: DAB staining.
ab84876 has not yet been referenced specifically in any publications.