Anti-Forkhead box protein O/dFOXO antibody - N-terminal (ab195977)

Overview

  • Product name

    Anti-Forkhead box protein O/dFOXO antibody - N-terminal
  • Description

    Rabbit polyclonal to Forkhead box protein O/dFOXO - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Drosophila melanogaster
  • Immunogen

    Synthetic peptide corresponding to Drosophila melanogaster Forkhead box protein O/dFOXO (N terminal).
    Database link: Q95V55

  • General notes

    Previously labelled as Forkhead box protein O. 

Properties

  • Form

    Lyophilised:Reconstitute with 100 uL distilled water.
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Constituents: 1.21% Tris buffer, 0.75% Glycine, 2% Sucrose
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG

Applications

Our Abpromise guarantee covers the use of ab195977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 67 kDa.

Target

  • Function

    Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.
  • Sequence similarities

    Contains 1 fork-head DNA-binding domain.
  • Cellular localization

    Cytoplasm. Nucleus. When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.
  • Information by UniProt
  • Database links

    • Alternative names

      • dFOXO antibody
      • Forkhead box protein O antibody
      • foxo antibody
      • FOXO_DROME antibody
      • Protein FKHR antibody
      see all

    References

    This product has been referenced in:

    • Zhai Y  et al. Quantitative Proteomic and Transcriptomic Analyses of Metabolic Regulation of Adult Reproductive Diapause in Drosophila suzukii (Diptera: Drosophilidae) Females. Front Physiol 10:344 (2019). Read more (PubMed: 31019467) »
    • Guo P  et al. Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells. Mol Med Rep 13:3539-46 (2016). Read more (PubMed: 26936536) »
    See all 2 Publications for this product

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