Formestane, Type I steroidal aromatase inhibitor (ab143116)

Overview

  • Product name

    Formestane, Type I steroidal aromatase inhibitor
  • Description

    Selective, irreversible and competitive type I steroidal aromatase inhibitor
  • Biological description

    Selective, irreversible and competitive type I steroidal aromatase inhibitor. Shows minor androgenic activity. Reduces plasma levels of estrogen and shows antitumor effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    566-48-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
  • Molecular weight

    302.41
  • Molecular formula

    C19H26O3
  • PubChem identifier

    11273
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C(C(=C2[C@](C1)([C@]3([C@@](CC2)([C@]4([C@](CC3)(C(CC4)=O)C)[H])[H])[H])C)O)=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Dean SL  et al. Prostaglandin E2 stimulates estradiol synthesis in the cerebellum postnatally with associated effects on Purkinje neuron dendritic arbor and electrophysiological properties. Endocrinology 153:5415-27 (2012). Read more (PubMed: 23054057) »
  • Nisslein T & Freudenstein J Coadministration of the aromatase inhibitor formestane and an isopropanolic extract of black cohosh in a rat model of chemically induced mammary carcinoma. Planta Med 73:318-22 (2007). Read more (PubMed: 17354167) »
  • Czerny B  et al. Effect of 4-hydroxyandrost-4-ene-3,17-dione (formestane) on the bile secretion and metabolism of 4-(14)C-cholesterol to bile acids. Pharmacol Rep 57:896-900 (0). Read more (PubMed: 16382215) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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