Formononetin, Testosterone 5alpha-reductase inhibitor (ab142878)

Overview

  • Product name

    Formononetin, Testosterone 5alpha-reductase inhibitor
  • Description

    Estrogenic agent. Testosterone 5α-reductase inhibitor.
  • Biological description

    Estrogenic agent. Testosterone 5α-reductase inhibitor. Binds to hER-α. Slight induction of transcription with hER-β. Antihypertensive effects in vivo.
  • Purity

    > 90%
  • CAS Number

    485-72-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-Hydroxy-3-(4-methoxyphenyl)chromen-4-one
  • Molecular weight

    268.26
  • Molecular formula

    C16H12O4
  • PubChem identifier

    5280378
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sun T  et al. Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT2A/1B receptors and a1-adrenoceptors in spontaneously rat arteries. Eur J Pharmacol 699:241-9 (2013). Read more (PubMed: 23123056) »
  • Bae M  et al. Inhibitory effects of isoflavonoids on rat prostate testosterone 5a-reductase. J Acupunct Meridian Stud 5:319-22 (2012). Read more (PubMed: 23265084) »
  • Auyeung KK  et al. Novel anti-angiogenic effects of formononetin in human colon cancer cells and tumor xenograft. Oncol Rep 28:2188-94 (2012). Read more (PubMed: 23023137) »

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