Overview

  • Product name

    Fosinopril sodium, Competitive ACE inhibitor
  • Description

    Competitive ACE inhibitor
  • Biological description

    Competitive ACE inhibitor. Prodrug of metabolite fosinoprilat. Shows antihypertensive effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    88889-14-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,4S)-4-Cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)
    phosphoryl]acetyl]pyrrolidine-2-carboxylate sodium
  • Molecular weight

    585.64
  • Molecular formula

    C30H45NNaO7P
  • PubChem identifier

    23681451
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C(=O)[O])C3CCCCC3.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhang YC  et al. Fosinopril attenuates the doxorubicin-induced cardiomyopathy by restoring the function of sarcoplasmic reticulum. Cell Biochem Biophys 64:205-11 (2012). Read more (PubMed: 22729889) »
  • Thakur AB  et al. Mechanism and kinetics of metal ion-mediated degradation of fosinopril sodium. Pharm Res 10:800-9 (1993). Read more (PubMed: 8391696) »
  • Ondetti MA Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation 77:I74-8 (1988). Read more (PubMed: 2836111) »

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