• Product name

  • Description

    Rabbit polyclonal to FOXC2
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Cow, Dog
  • Immunogen

    A region within synthetic peptide: ASPALPVITK VETLSPESAL QGSPRSAAST PAGSPDGSLP EHHAAAPNGL, corresponding to internal sequence amino acids 218-267 of Human FOXC2



Our Abpromise guarantee covers the use of ab24340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 56 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function

    Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.
  • Involvement in disease

    Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2) [MIM:153200]; also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment.
    Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN) [MIM:153300]. LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities.
    Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD) [MIM:153400]. LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).
  • Sequence similarities

    Contains 1 fork-head DNA-binding domain.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • Drosphilia Forkhead Homolog Like 14 antibody
    • FKHL 14 antibody
    • FKHL14 antibody
    • Forkhead Box C2 antibody
    • Forkhead box protein C2 antibody
    • Forkhead related protein FKHL14 antibody
    • Forkhead-related protein FKHL14 antibody
    • FOX C2 antibody
    • Foxc2 antibody
    • FOXC2_HUMAN antibody
    • LD antibody
    • Mesenchyme fork head protein 1 antibody
    • Mesenchyme Forkhead 1 antibody
    • MFH 1 antibody
    • MFH 1 protein antibody
    • MFH-1 protein antibody
    • MFH1 antibody
    • Transcription factor FKH 14 antibody
    • Transcription factor FKH-14 antibody
    see all


  • Anti-FOXC2 antibody (ab24340) at 0.6 µg/ml
    Predicted band size: 56 kDa
    Observed band size: 60 kDa
    why is the actual band size different from the predicted?

    ab24340 staining FOXC2 in Fetal Kidney Lysate (Human) by Western Blot. Gel concentration 12%.


This product has been referenced in:

  • Zhang W  et al. Foxc2 and BMP2 Induce Osteogenic/Odontogenic Differentiation and Mineralization of Human Stem Cells from Apical Papilla. Stem Cells Int 2018:2363917 (2018). Read more (PubMed: 30147726) »
  • Jag UR  et al. Insulin acts through FOXO3a to activate transcription of plasminogen activator inhibitor type 1. Mol Endocrinol 23:1587-602 (2009). WB ; Human . Read more (PubMed: 19608644) »
See all 2 Publications for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A


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Read More
Western blot
Human Cell lysate - whole cell (T47D Breast Cancer cell line)
Loading amount
100 µg
T47D Breast Cancer cell line
10nM siRNA 48 hrs
Blocking step
Milk as blocking agent for 3 hour(s) and 0 minute(s) · Concentration: 5%

Dr. F Stanley

Verified customer

Submitted Mar 23 2007

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