• Product name
  • Description
    Rabbit polyclonal to FOXF1
  • Host species
  • Tested applications
    Suitable for: ICC/IF, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Chicken, Cow, Dog, Xenopus laevis
  • Immunogen

    Synthetic peptide within FOXF1 aa 292-341 (C terminal). The exact sequence is proprietary.


    Database link: Q12946

  • Positive control
    • Fetal placental lysate.



Our Abpromise guarantee covers the use of ab23194 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 21341990
IHC-P Use at an assay dependent concentration. PubMed: 20722018
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 40 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    Probable transcription activator for a number of lung-specific genes.
  • Tissue specificity
    Lung and placenta.
  • Involvement in disease
    Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]. ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
  • Sequence similarities
    Contains 1 fork-head DNA-binding domain.
  • Domain
    Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • AI450827 antibody
    • FKH L5 antibody
    • FKHL 5 antibody
    • FKHL5 antibody
    • Forkhead (Drosophila) like 5 antibody
    • Forkhead box F1 antibody
    • Forkhead box protein F1 antibody
    • Forkhead drosophila homolog like 5 antibody
    • Forkhead like 5 antibody
    • Forkhead related activator 1 antibody
    • Forkhead related protein FKHL5 antibody
    • Forkhead related transcription factor 1 antibody
    • Forkhead-related activator 1 antibody
    • Forkhead-related protein FKHL5 antibody
    • Forkhead-related transcription factor 1 antibody
    • FOX F1 antibody
    • FOXF 1 antibody
    • foxf1 antibody
    • FOXF1_HUMAN antibody
    • FREAC 1 antibody
    • FREAC-1 antibody
    • FREAC1 antibody
    • HFH 8 antibody
    • MGC105125 antibody
    see all



This product has been referenced in:
  • Wei HJ  et al. FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells. Oncotarget 5:9514-29 (2014). WB ; Human . Read more (PubMed: 25237908) »
  • Bozyk PD  et al. Mesenchymal stromal cells from neonatal tracheal aspirates demonstrate a pattern of lung-specific gene expression. Stem Cells Dev 20:1995-2007 (2011). ICC/IF ; Human . Read more (PubMed: 21341990) »

See all 3 Publications for this product

Customer reviews and Q&As

Expiration date: 27th of February 2013

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I can confirm that the antibodies ab5081 and ab23194 have been raised against different immunogens. The antibody ab5081 was raised against a synthetic peptide taken from the residu...

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