FPS-ZM1, RAGE receptor antagonist (ab235552)

Overview

  • Product name

    FPS-ZM1, RAGE receptor antagonist
  • Description

    High-affinity RAGE receptor antagonist
  • Biological description

    High-affinity, blood-brain-barrier permeable, non-toxic, tertiary amide RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). Blocks Aβ binding to the V domain of RAGE. Inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo.

  • Purity

    > 98%
  • CAS Number

    945714-67-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide

  • Molecular weight

    327.85
  • Molecular formula

    C20H22ClNO
  • PubChem identifier

    24752728
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 198.26 mM and in ethanol to 198.26 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCC(CC1)N(CC2=CC=CC=C2)C(=O)C3=CC=C(C=C3)Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Hong Y  et al. Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-ß Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem Res 41:1192-9 (2016). Read more (PubMed: 26738988) »
  • Deane R  et al. A multimodal RAGE-specific inhibitor reduces amyloid ß-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest 122:1377-92 (2012). Read more (PubMed: 22406537) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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