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    fra2-antibody-epr47132-ab124830.pdf

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Epigenetics and Nuclear Signaling Transcription Domain Families HLH / Leucine Zipper Leucine Zipper
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RecombinantRabMAb

Recombinant Anti-FRA2 antibody [EPR4713(2)] (ab124830)

  • Datasheet
  • SDS
Submit a review Submit a question References (5)

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Western blot - Anti-FRA2 antibody [EPR4713(2)] (ab124830)
  • Flow Cytometry - Anti-FRA2 antibody [EPR4713(2)] (ab124830)
  • Anti-FRA2 antibody [EPR4713(2)] (ab124830)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR4713(2)] to FRA2
  • Suitable for: WB, Flow Cyt
  • Reacts with: Mouse, Rat, Human

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Overview

  • Product name

    Anti-FRA2 antibody [EPR4713(2)]
    See all FRA2 primary antibodies
  • Description

    Rabbit monoclonal [EPR4713(2)] to FRA2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ICC or IHC-P
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human FRA2 aa 250-350 (C terminal). The exact sequence is proprietary.

  • Positive control

    • 293T cells; MCF7, F9, PC12, NCCIT, and 293T cell lysates.
  • General notes

     

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.20
    Preservative: 0.05% Sodium azide
    Constituents: 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR4713(2)
  • Isotype

    IgG
  • Research areas

    • Epigenetics and Nuclear Signaling
    • Transcription
    • Domain Families
    • HLH / Leucine Zipper
    • Leucine Zipper
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Cancer susceptibility
    • Proto-oncogenes

Associated products

  • Alternative Versions

    • Anti-FRA2 antibody [EPR4713(2)] - BSA and Azide free (ab248024)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • Positive Controls

    • MCF7 nuclear extract lysate (ab14860)
    • PC-12 nuclear extract lysate (ab14884)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab124830 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/1000 - 1/10000. Detects a band of approximately 46 kDa (predicted molecular weight: 35 kDa).
Flow Cyt
1/100 - 1/500.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

Notes
WB
1/1000 - 1/10000. Detects a band of approximately 46 kDa (predicted molecular weight: 35 kDa).
Flow Cyt
1/100 - 1/500.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

  • Application notes
    Is unsuitable for ICC or IHC-P.
  • Target

    • Function

      Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts.
    • Sequence similarities

      Belongs to the bZIP family. Fos subfamily.
      Contains 1 bZIP (basic-leucine zipper) domain.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession P15408 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 2355 Human
      • Entrez Gene: 14284 Mouse
      • Entrez Gene: 25446 Rat
      • Omim: 601575 Human
      • SwissProt: P15408 Human
      • SwissProt: P47930 Mouse
      • SwissProt: P51145 Rat
      • Unigene: 220971 Human
      • Unigene: 596972 Human
      • Unigene: 24684 Mouse
      • Unigene: 10962 Rat
      • Unigene: 163577 Rat
      see all
    • Alternative names

      • FLJ23306 antibody
      • Fos L2 antibody
      • FOS like antigen 2 antibody
      • Fos related antigen 2 antibody
      • Fos-related antigen 2 antibody
      • FosL 2 antibody
      • Fosl2 antibody
      • FOSL2_HUMAN antibody
      • FRA 2 antibody
      • FRA-2 antibody
      see all

    Images

    • Western blot - Anti-FRA2 antibody [EPR4713(2)] (ab124830)
      Western blot - Anti-FRA2 antibody [EPR4713(2)] (ab124830)
      All lanes : Anti-FRA2 antibody [EPR4713(2)] (ab124830) at 1/1000 dilution

      Lane 1 : MCF7 cell lysate
      Lane 2 : F9 cell lysate
      Lane 3 : PC12 cell lysate
      Lane 4 : NCCIT cell lysate
      Lane 5 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 35 kDa

    • Flow Cytometry - Anti-FRA2 antibody [EPR4713(2)] (ab124830)
      Flow Cytometry - Anti-FRA2 antibody [EPR4713(2)] (ab124830)
      ab124830 at 1/100 dilution staining FRA2 in permeabilized 293T cells (red). A rabbit IgG was used as negative control (green).
    • Anti-FRA2 antibody [EPR4713(2)] (ab124830)
      Anti-FRA2 antibody [EPR4713(2)] (ab124830)

    Protocols

    • Western blot protocols
    • Flow cytometry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (5)

    Publishing research using ab124830? Please let us know so that we can cite the reference in this datasheet.

    ab124830 has been referenced in 5 publications.

    • Song LN  et al. Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging miR-143-3p and PCBP1. J Exp Clin Cancer Res 39:114 (2020). PubMed: 32552766
    • Ren W  et al. Calcitonin gene-related peptide regulates FOSL2 expression and cell proliferation of BMSCs via mmu_circRNA_003795. Mol Med Rep 19:3732-3742 (2019). PubMed: 30896827
    • Li Z  et al. lncRNA UCA1 Mediates Resistance to Cisplatin by Regulating the miR-143/FOSL2-Signaling Pathway in Ovarian Cancer. Mol Ther Nucleic Acids 17:92-101 (2019). PubMed: 31234009
    • He J  et al. miR-597 inhibits breast cancer cell proliferation, migration and invasion through FOSL2. Oncol Rep 37:2672-2678 (2017). WB ; Human . PubMed: 28393251
    • Renaud SJ  et al. The FOS transcription factor family differentially controls trophoblast migration and invasion. J Biol Chem 289:5025-39 (2014). WB ; Human . PubMed: 24379408

    Customer reviews and Q&As

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