Key features and details
- Rabbit polyclonal to FREM1
- Suitable for: WB, ELISA, IHC-P, ICC
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FREM1 antibody
See all FREM1 primary antibodies
DescriptionRabbit polyclonal to FREM1
Tested applicationsSuitable for: WB, ELISA, IHC-P, ICCmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Synthetic peptide conjugated to KLH, from the C terminus of Human FREM1.
- Human tonsil tissue.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab117566 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 244 kDa.|
|ELISA||Use at an assay dependent concentration.|
|IHC-P||Use a concentration of 10 µg/ml.|
|ICC||Use at an assay dependent concentration.|
FunctionExtracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development.
Involvement in diseaseDefects in FREM1 are the cause of bifid nose with or without anorectal and renal anomalies (BNAR) [MIM:608980]. A bifid nose is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation. BNAR is an autosomal recessive disorder and patients usually present a bifid nose associated with renal and anorectal malformations.
Sequence similaritiesBelongs to the FRAS1 family.
Contains 1 C-type lectin domain.
Contains 1 Calx-beta domain.
Contains 12 CSPG (NG2) repeats.
DomainThe Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding.
Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane. Localizes at the basement membrane zone of embryonic epidermis and hair follicles.
- Information by UniProt
- BC037594 antibody
- BNAR antibody
- C9orf143 antibody
ab117566 has not yet been referenced specifically in any publications.