Overview

  • Product name

  • Description

    Rabbit polyclonal to FREM1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ELISA, IHC-P, ICCmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, from the C terminus of Human FREM1.

  • Positive control

    • Human tonsil tissue.
  • General notes

    Stable for one year at 4°C.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab117566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 244 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml.
ICC Use at an assay dependent concentration.

Target

  • Function

    Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development.
  • Involvement in disease

    Defects in FREM1 are the cause of bifid nose with or without anorectal and renal anomalies (BNAR) [MIM:608980]. A bifid nose is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation. BNAR is an autosomal recessive disorder and patients usually present a bifid nose associated with renal and anorectal malformations.
  • Sequence similarities

    Belongs to the FRAS1 family.
    Contains 1 C-type lectin domain.
    Contains 1 Calx-beta domain.
    Contains 12 CSPG (NG2) repeats.
  • Domain

    The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix > basement membrane. Localizes at the basement membrane zone of embryonic epidermis and hair follicles.
  • Information by UniProt
  • Database links

  • Alternative names

    • BC037594 antibody
    • BNAR antibody
    • C9orf143 antibody
    • C9orf145 antibody
    • C9orf154 antibody
    • D430009N09 antibody
    • D630008K06 antibody
    • FLJ25461 antibody
    • FRAS1-related extracellular matrix protein 1 antibody
    • FREM 1 antibody
    • FREM1 antibody
    • FREM1_HUMAN antibody
    • Heb antibody
    • MOTA antibody
    • Protein QBRICK antibody
    • QBRICK antibody
    • RGD1306981 antibody
    • RP11-265B7.2 antibody
    • RP23-410K19.1 antibody
    • TILRR antibody
    see all

Images

  • ab117566, at 10 µg/ml, staining FREM1 in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.

References

ab117566 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab117566.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up