Key features and details
- Rabbit polyclonal to FREM2
- Suitable for: WB, ELISA, IHC-P, ICC
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FREM2 antibody
DescriptionRabbit polyclonal to FREM2
Tested applicationsSuitable for: WB, ELISA, IHC-P, ICCmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Synthetic peptide conjugated to KLH, corresponding to 19 internal sequence amino acids of Human FREM2.
- Human Breast and Human Kidney tissues.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab117612 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 351 kDa.|
|ELISA||Use at an assay dependent concentration.|
|IHC-P||Use a concentration of 5 µg/ml.|
|ICC||Use at an assay dependent concentration.|
FunctionExtracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.
Involvement in diseaseDefects in FREM2 are a cause of Fraser syndrome (FRASS) [MIM:219000]. Fraser syndrome is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects.
Sequence similaritiesBelongs to the FRAS1 family.
Contains 5 Calx-beta domains.
Contains 12 CSPG (NG2) repeats.
DomainThe Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.
Cellular localizationCell membrane.
- Information by UniProt
- DKFZp781I048 antibody
- ECM3 homolog antibody
- FRAS1-related extracellular matrix protein 2 antibody
ab117612 has not yet been referenced specifically in any publications.