Recombinant Anti-Frizzled 9 antibody [EPR4011] (ab108628)


  • Product name

    Anti-Frizzled 9 antibody [EPR4011]
    See all Frizzled 9 primary antibodies
  • Description

    Rabbit monoclonal [EPR4011] to Frizzled 9
  • Host species

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Frizzled 9. The exact sequence is proprietary.

  • Positive control

    • Human seminoma, fetal kidney and fetal testis lysates
  • General notes



    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab108628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 65 kDa (predicted molecular weight: 64 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    • Tissue specificity

      Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.
    • Sequence similarities

      Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • Domain

      Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • Cellular localization

      Cell membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • CD 349 antibody
      • CD 349 antigen antibody
      • CD349 antibody
      • Frizzled Drosophila homolog of 3 antibody
      • Frizzled homolog 9 (Drosophila) antibody
      • Frizzled homolog 9 antibody
      • Frizzled-9 antibody
      • Fz 9 antibody
      • Fz-9 antibody
      • FZD 3 antibody
      • Fzd 9 antibody
      • FZD3 antibody
      • FZD3-PEN antibody
      • FZD9 antibody
      • FZD9_HUMAN antibody
      • FzE6 antibody
      • hFz9 antibody
      • mfz9 antibody
      • Xfz9 antibody
      see all


    • All lanes : Anti-Frizzled 9 antibody [EPR4011] (ab108628) at 1/1000 dilution

      Lane 1 : Human Seminoma lysate
      Lane 2 : Human fetal kidney lysate
      Lane 3 : Human fetal testis lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 64 kDa
      Observed band size: 65 kDa
      why is the actual band size different from the predicted?


    ab108628 has not yet been referenced specifically in any publications.

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