Anti-FRK antibody [4E1] (ab91623)
Key features and details
- Mouse monoclonal [4E1] to FRK
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-FRK antibody [4E1]
See all FRK primary antibodies -
Description
Mouse monoclonal [4E1] to FRK -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Purified recombinant fragment of Human FRK expressed in E. Coli.
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Positive control
- K562 cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
Purified from tissue culture supernatant. -
Clonality
Monoclonal -
Clone number
4E1 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab91623 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/2000. Predicted molecular weight: 58 kDa.
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Notes |
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WB
1/500 - 1/2000. Predicted molecular weight: 58 kDa. |
Target
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Function
Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor. -
Tissue specificity
Restricted to cells lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 2444 Human
- Omim: 606573 Human
- SwissProt: P42685 Human
- Unigene: 89426 Human
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Alternative names
- Beta cell Src homology tyrosine kinase antibody
- BSK antibody
- BSK/IYK antibody
see all
Images
Datasheets and documents
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Datasheet download
References (1)
ab91623 has been referenced in 1 publication.
- de Wispelaere M et al. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol 87:7367-81 (2013). PubMed: 23616652