Overview

  • Product name

    Anti-FRK antibody [4E1]
    See all FRK primary antibodies
  • Description

    Mouse monoclonal [4E1] to FRK
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Purified recombinant fragment of Human FRK expressed in E. Coli.

  • Positive control

    • K562 cell lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    Purified from tissue culture supernatant.
  • Clonality

    Monoclonal
  • Clone number

    4E1
  • Isotype

    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab91623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 58 kDa.
ELISA 1/10000.

Target

  • Function

    Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
  • Tissue specificity

    Restricted to cells lines derived from tissues of lymphoid, brain, breast, colon and bladder origin.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • Beta cell Src homology tyrosine kinase antibody
    • BSK antibody
    • BSK/IYK antibody
    • C85044 antibody
    • Frk antibody
    • Frk fyn related kinase antibody
    • FRK_HUMAN antibody
    • FYN related kinase antibody
    • FYN-related kinase antibody
    • GASK antibody
    • Gastrointestinal associated kinase antibody
    • Gastrointestinal associated tyrosine kinase antibody
    • GTK antibody
    • GTK, mouse, homolog of antibody
    • Intestine tyrosine kinase antibody
    • Nuclear tyrosine protein kinase RAK antibody
    • Protein-tyrosine kinase 5 antibody
    • PTK5 antibody
    • PTK5 protein tyrosine kinase 5 antibody
    • RAK antibody
    • Tyrosine protein kinase FRK antibody
    • Tyrosine-protein kinase FRK antibody
    see all

Images

  • Anti-FRK antibody [4E1] (ab91623) at 1/500 dilution + K562 cell lysate

    Predicted band size: 58 kDa

References

This product has been referenced in:

  • de Wispelaere M  et al. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol 87:7367-81 (2013). Read more (PubMed: 23616652) »
See 1 Publication for this product

Customer reviews and Q&As

Answer

Thank you for contacting us.
CCK4
ab104839 was generated against amino acids x-y.

RON
ab93129 was generated against a partial recombinant protein containing the protein sequence spanning 163-514. A his-tag was used in the protein.

ROR2
ab92379 The peptide maps between amino acids 40 and 65 of human ROR2 (UniProt: Q01974), i.e. an extracellular epitope is detected.
ab80174 The antigen is recorded in our system as a his-tag fusion protein, without specifying whether it is a partial or full-length recombinant protein. We apologise that more information is currently not available.

Fgr
ab81599 was generated against amino acids 2-100.
ab92302 The peptide maps between amino acids 25 and 50 of human FGR (UniProt: P09769)
ab65007 The amino acid range for this immunogen is 61-110 from human FGR (P09769).

Fer
ab109740 The recombinant protein used as the immunogen for this antibody encodes amino acids x-y.
Brk
ab52273 was generated against amino acids 2-175.

Fes
ab108418 The peptide maps between amino acids 760 and 790 of human FES (UniProt: P07332).

Frk
ab91623 was generated against amino acids x-y.

Fyn
ab119855 was generated against amino acids 7-176

Csk
ab125005 The peptide maps between amino acids 75 and 105 of human CSK (UniProt: P41240)

Lyn
ab52563 see attachment

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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