Overview

  • Product name

  • Description

    Rabbit polyclonal to FRS2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Xenopus laevis, Xenopus tropicalis
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-232 of Human FRS2 (UniProt ID: Q8WU20).

  • Positive control

    • 293T, A431, H1299, HeLaS3, HepG2 and Raji whole cell lysates.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab137458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 57 kDa.

Target

  • Function

    Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
  • Tissue specificity

    Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
  • Sequence similarities

    Contains 1 IRS-type PTB domain.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues upon stimulation by NGF.
    Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.
  • Cellular localization

    Endomembrane system. Cytoplasmic, membrane-bound.
  • Information by UniProt
  • Database links

  • Alternative names

    • FGFR signaling adaptor SNT antibody
    • FGFR signalling adaptor antibody
    • FGFR substrate 2 antibody
    • FGFR-signaling adaptor SNT antibody
    • Fibroblast growth factor receptor substrate 2 antibody
    • FRS 2 antibody
    • FRS2 antibody
    • FRS2_HUMAN antibody
    • FRS2A antibody
    • FRS2alpha antibody
    • SNT 1 antibody
    • SNT antibody
    • SNT-1 antibody
    • SNT1 antibody
    • Suc 1 Associated Neurotrophic Factor Target antibody
    • Suc1 associated neurotrophic factor target 1 antibody
    • Suc1-associated neurotrophic factor target 1 antibody
    see all

Images

  • All lanes : Anti-FRS2 antibody (ab137458) at 1/500 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HeLaS3 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 57 kDa



    7.5% SDS PAGE

References

This product has been referenced in:

  • Kabashima A  et al. Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma. J Hepatol 68:1228-1238 (2018). WB . Read more (PubMed: 29408314) »
  • Rafii S  et al. Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration. Nat Cell Biol 17:123-136 (2015). Read more (PubMed: 25621952) »
See all 2 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab137458.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up