Anti-FSH-R antibody (ab113421)
Key features and details
- Rabbit polyclonal to FSH-R
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-FSH-R antibody
See all FSH-R primary antibodies -
Description
Rabbit polyclonal to FSH-R -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ICC/IFmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human FSH-R aa 278-327 (internal sequence).
Database link: P23945 -
Positive control
- Human Ovary tissue; MCF7 cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride
PBS (without Mg2+, Ca2+) -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab113421 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 10 µg/ml.
|
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ICC/IF | (1) |
1/100 - 1/500.
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Notes |
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IHC-P
Use a concentration of 10 µg/ml. |
ICC/IF
1/100 - 1/500. |
Target
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Function
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. -
Tissue specificity
Sertoli cells and ovarian granulosa cells. -
Involvement in disease
Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain. -
Post-translational
modificationsN-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 2492 Human
- Omim: 136435 Human
- SwissProt: P23945 Human
- Unigene: 1428 Human
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Alternative names
- Follicle stimulating hormone receptor antibody
- Follicle stimulating hormone receptor isoform 1 antibody
- Follicle-stimulating hormone receptor antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (10)
ab113421 has been referenced in 10 publications.
- Li H et al. Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosis. Int J Biol Sci 18:1008-1021 (2022). PubMed: 35173533
- Zou J et al. Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis. J Ovarian Res 15:30 (2022). PubMed: 35227296
- Li H et al. Case report: Birth achieved after effective ovarian stimulation combined with dexamethasone in a patient with resistant ovary syndrome. J Ovarian Res 15:42 (2022). PubMed: 35392972
- Sheng S et al. Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer In Vitro and In Vivo. Int J Environ Res Public Health 19:N/A (2022). PubMed: 36430063
- Zuo W et al. Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment. Nat Commun 12:5827 (2021). PubMed: 34625553
- Olejar T et al. The FSHR Expression in Head and Neck Squamous Cell Cancer. A Pilot Immunohistochemical Study. Anticancer Res 40:349-356 (2020). PubMed: 31892586
- Candelaria JI et al. Ovarian preantral follicles are responsive to FSH as early as the primary stage of development. J Endocrinol 247:153-168 (2020). PubMed: 32805705
- Xu D et al. SIRT2 plays a novel role on progesterone, estradiol and testosterone synthesis via PPARs/LXRa pathways in bovine ovarian granular cells. J Steroid Biochem Mol Biol 185:27-38 (2019). PubMed: 30009951
- Cai H et al. Identification and characterization of human ovary-derived circular RNAs and their potential roles in ovarian aging. Aging (Albany NY) 10:2511-2534 (2018). PubMed: 30260796
- Li M et al. Reduced expression of follicle stimulating hormone receptor mRNA and protein in pregnancies complicated by pre-eclampsia. Mol Med Rep 16:367-372 (2017). PubMed: 28534997