Product nameAnti-FSH-R antibody
See all FSH-R primary antibodies
DescriptionRabbit polyclonal to FSH-R
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human FSH-R aa 631-695 (C terminal).
Database link: P23945
- A431, H1299, HeLa, HepG2 and Raji cells.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab137695 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 78 kDa.|
FunctionReceptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Tissue specificitySertoli cells and ovarian granulosa cells.
Involvement in diseaseDefects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.
modificationsN-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.
Cellular localizationCell membrane.
- Information by UniProt
- Follicle stimulating hormone receptor antibody
- Follicle stimulating hormone receptor isoform 1 antibody
- Follicle-stimulating hormone receptor antibody
All lanes : Anti-FSH-R antibody (ab137695) at 1/500 dilution
Lane 1 : Whole cell lysate prepared from A431 cells
Lane 2 : Whole cell lysate prepared from H1299 cells
Lane 3 : Whole cell lysate prepared from Hela cells
Lane 4 : Whole cell lysate prepared from HepG2 cells
Lysates/proteins at 30 µg per lane.
Predicted band size: 78 kDa
7.5% SDS PAGE
This product has been referenced in:
- Zhou P et al. IGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cells. Mol Endocrinol 27:511-23 (2013). WB ; Mouse, Rat, Human . Read more (PubMed: 23340251) »
- Efimenko E et al. The transcription factor GATA4 is required for follicular development and normal ovarian function. Dev Biol 381:144-58 (2013). Read more (PubMed: 23769843) »