Key features and details
- Rat monoclonal [RM0080-7D11] to FSTL3
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferConstituent: PBS
Concentration information loading...
PurityProtein A purified
Purification notesThe IgG fraction of culture supernatant was purified by Protein A affinity chromatography filtered sterilized.
Our Abpromise guarantee covers the use of ab86055 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 28 kDa.|
FunctionIsoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
Tissue specificityExpressed in a wide range of tissues.
Involvement in diseaseNote=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
Sequence similaritiesContains 2 follistatin-like domains.
Contains 2 Kazal-like domains.
Contains 1 TB (TGF-beta binding) domain.
Cellular localizationSecreted and Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
- Information by UniProt
- FLRG antibody
- follistatin-like 3 antibody
- follistatin-like 3 glycoprotein antibody
ab86055 has not yet been referenced specifically in any publications.