Fumagillin, methionine aminopeptidase-2 (MetAP2) inhibitor (ab141527)

Overview

  • Product name

    Fumagillin, methionine aminopeptidase-2 (MetAP2) inhibitor
  • Description

    Potent, selective and covalent methionine aminopeptidase-2 (MetAP2) inhibitor. Anti-angiogenic.
  • Biological description

    Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2) (IC50 = 9.2 nM). Anti-angiogenic. Inhibits endothelial cell proliferation. Inhibits neovascularization and reduces diet-induced obesity in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    23110-15-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    10-[[5-Methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro
    [2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
  • Molecular weight

    458.50
  • Molecular formula

    C26H34O7
  • PubChem identifier

    3430
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kilarski WW  et al. An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels. Angiogenesis 15:643-55 (2012). Read more (PubMed: 22918697) »
  • Lijnen HR  et al. Fumagillin reduces adipose tissue formation in murine models of nutritionally induced obesity. Obesity (Silver Spring) 18:2241-6 (2010). Read more (PubMed: 20094042) »
  • Kwon JY  et al. cis-fumagillin, a new methionine aminopeptidase (type 2) inhibitor produced by Penicillium sp. F2757. J Antibiot (Tokyo) 53:799-806 (2000). Read more (PubMed: 11079802) »
  • Sin N  et al. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc Natl Acad Sci U S A 94:6099-103 (1997). Read more (PubMed: 9177176) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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