Overview

  • Product name

    Anti-Fumarylacetoacetate hydrolase/FAA antibody
    See all Fumarylacetoacetate hydrolase/FAA primary antibodies
  • Description

    Rabbit polyclonal to Fumarylacetoacetate hydrolase/FAA
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Recombinant fragment corresponding to Human Fumarylacetoacetate hydrolase/FAA aa 185-419.
    Database link: P16930

  • Positive control

    • ICC/IF: HeLa cells. WB: Mouse liver and kidney lysates; A549 whole cell extract.
  • General notes

    Previously labelled as Fumarylacetoacetate hydrolase. 

Properties

Applications

Our Abpromise guarantee covers the use of ab151998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 46 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Relevance

    Fumarylacetoacetate hydrolase / FAA is the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia (HT). This is an autosomal recessive inborn error of metabolism that occurs in both an acute and a chronic form. Clinical characteristics of the acute form include hepatic failure and death in infancy, whereas children with the chronic form have renal tubular dysfunction and hypophosphatemic rickets, progressive liver disease with development of hepatocellular carcinoma. Dietary treatment with restriction of tyrosine and phenylalanine alleviates the rickets, but liver transplantation has so far been the only definite treatment.
  • Database links

  • Alternative names

    • Beta diketonase antibody
    • FAA antibody
    • FAH antibody
    • Fumarylacetoacetase antibody
    • Fumarylacetoacetate antibody
    • Fumarylacetoacetate hydrolase antibody
    see all

Images

  • Anti-Fumarylacetoacetate hydrolase/FAA antibody (ab151998) at 1/1000 dilution + Mouse liver lysate at 50 µg

    Predicted band size: 46 kDa

  • Anti-Fumarylacetoacetate hydrolase/FAA antibody (ab151998) at 1/1000 dilution + Mouse kidney lysate at 50 µg

    Predicted band size: 46 kDa

  • Anti-Fumarylacetoacetate hydrolase/FAA antibody (ab151998) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size: 46 kDa



    10% SDS PAGE
  • Immunofluorescent analysis of methanol-fixed HeLa cells labeling Fumarylacetoacetate hydrolase/FAA with ab151998 at 1/200 dilution. Lower panel co-stained with Hoechst 33342.

References

ab151998 has not yet been referenced specifically in any publications.

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