Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent (ab144258)

Overview

  • Product name
    Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent
  • Description
    Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor.
  • Biological description
    Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor. Selectively reverses resistance to and potentiates mitoxantrone (ab145668), doxorubicin (ab120629) and topotecan (ab120388) in BCRP-transfected cells. Mycotoxin. Shows antiproliferative effects. Shows tremorgenic effects in vivo.
  • Purity
    > 98%
  • CAS Number
    118974-02-0
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • González-Lobato L  et al. Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C. Eur J Pharmacol 644:41-8 (2010). Read more (PubMed: 20655304) »
  • Wang L  et al. Establishment of a luciferase assay-based screening system: fumitremorgin C selectively inhibits cellular proliferation of immortalized astrocytes expressing an active form of AKT. Biochem Biophys Res Commun 373:392-6 (2008). Read more (PubMed: 18570889) »
  • Rabindran SK  et al. Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res 60:47-50 (2000). Read more (PubMed: 10646850) »
See 1 Publication for this product

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