Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent (ab144258)

Overview

  • Product name
    Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent
  • Description
    Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor.
  • Biological description
    Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor. Selectively reverses resistance to and potentiates mitoxantrone (ab145668), doxorubicin (ab120629) and topotecan (ab120388) in BCRP-transfected cells. Mycotoxin. Shows antiproliferative effects. Shows tremorgenic effects in vivo.
  • Purity
    > 98%

Properties

  • Chemical name
    (5aS,12S,14aS)-1,2,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methylprop-1-en-1-yl)-5H,14H-pyrrolo[1'',4'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
  • Molecular weight
    379.45
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C22H25N3O3
  • CAS Number
    118974-02-0
  • PubChem identifier
    403923
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(=C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H]4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C
  • Source

    Aspergillus fumigatus

  • Research areas

References

This product has been referenced in:
  • González-Lobato L  et al. Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C. Eur J Pharmacol 644:41-8 (2010). Read more (PubMed: 20655304) »
  • Wang L  et al. Establishment of a luciferase assay-based screening system: fumitremorgin C selectively inhibits cellular proliferation of immortalized astrocytes expressing an active form of AKT. Biochem Biophys Res Commun 373:392-6 (2008). Read more (PubMed: 18570889) »
  • Rabindran SK  et al. Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res 60:47-50 (2000). Read more (PubMed: 10646850) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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