Fumonisin B1, Protein serine/threonine phosphatase inhibitor (ab142433)

Overview

  • Product name

    Fumonisin B1, Protein serine/threonine phosphatase inhibitor
  • Description

    Protein serine/threonine phosphatase inhibitor. Cell proliferation inhibitor and apoptosis inducer
  • Biological description

    Mycotoxin and protein serine/threonine phosphatase inhibitor (IC50 values are 80 μM (PP5), 0.3 (PP2Cα), 0.4 ( PP2A), 0.5 (PP1γ2) and 3 mM (PP2B)). Cell proliferation inhibitor and apoptosis inducer. Inhibits incorporation of [14C]serine into sphingosine moiety of cellular sphingolipids (IC50 = 0.1 μM). Toxicological and carginogenic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    116355-83-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Fukuda H  et al. Inhibition of protein serine/threonine phosphatases by fumonisin B1, a mycotoxin. Biochem Biophys Res Commun 220:160-5 (1996). Read more (PubMed: 8602837) »
  • Merrill AH  et al. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J Biol Chem 268:27299-306 (1993). Read more (PubMed: 8262970) »
  • Abbas HK  et al. Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures. Toxicon 31:345-53 (1993). Read more (PubMed: 8470138) »
  • Wang E  et al. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266:14486-90 (1991). Read more (PubMed: 1860857) »

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