Overview

  • Product name
    Anti-FVT1 antibody
    See all FVT1 primary antibodies
  • Description
    Rabbit polyclonal to FVT1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 65-296 of Human FVT1 (Uniprot ID Q06136)

  • Positive control
    • 293T | A431 | Jurkat | Raji whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab153960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 36 kDa.

Target

  • Function
    Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
  • Tissue specificity
    Expressed in all tissues examined. Highest expression in placenta. High expression in lung, kidney, stomach and small intestine, low expression in heart, spleen and skeletal muscle. Weakly expressed in normal hematopoietic tissues. Higher expression in some T-cell malignancies and PHA-stimulated lymphocytes.
  • Pathway
    Lipid metabolism; sphingolipid metabolism.
  • Involvement in disease
    A chromosomal aberration involving KDSR is a cause of follicular lymphoma; also known as type II chronic lymphatic leukemia. Translocation t(2;18)(p11;q21) with a Ig J kappa chain region (PubMed:8417785).
  • Sequence similarities
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • 3 dehydrosphinganine reductase antibody
    • 3 ketodihydrosphingosine reductase antibody
    • 3-dehydrosphinganine reductase antibody
    • 3-ketodihydrosphingosine reductase antibody
    • DHSR antibody
    • FLJ36555 antibody
    • FLJ92680 antibody
    • Follicular lymphoma variant translocation 1 antibody
    • Follicular variant translocation protein 1 antibody
    • FVT 1 antibody
    • FVT-1 antibody
    • FVT1 antibody
    • KDS reductase antibody
    • KDSR antibody
    • KDSR_HUMAN antibody
    • SDR35C1 antibody
    • Short chain dehydrogenase/reductase family 35C member 1 antibody
    see all

Images

  • Western blot - Anti-FVT1 antibody (ab153960)
    Western blot - Anti-FVT1 antibody (ab153960)
    Anti-FVT1 antibody (ab153960) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size: 36 kDa



    10% SDS PAGE

References

ab153960 has not yet been referenced specifically in any publications.

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