Overview

  • Product name

  • Description

    Rabbit polyclonal to FXI
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human FXI aa 21-282.
    Database link: NP_000119

  • Positive control

    • 293T whole cell lysate and Raji lysate.
  • General notes

    Previously labelled as Factor XI.

Properties

Applications

Our Abpromise guarantee covers the use of ab97346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 70 kDa.

Target

  • Function

    Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
  • Tissue specificity

    Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
  • Involvement in disease

    Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
  • Sequence similarities

    Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications

    Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Coagulation factor XI antibody
    • Coagulation factor XIa light chain antibody
    • F11 antibody
    • FA11_HUMAN antibody
    • Factor XI antibody
    • FXI antibody
    • MGC141891 antibody
    • Plasma thromboplastin antecedent antibody
    • PTA antibody
    see all

Images

  • Anti-FXI antibody (ab97346) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size: 70 kDa



    7.5% SDS PAGE

References

ab97346 has not yet been referenced specifically in any publications.

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