Key features and details
- Rabbit polyclonal to FXI
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FXI antibody
See all FXI primary antibodies
DescriptionRabbit polyclonal to FXI
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human FXI aa 21-282.
Database link: NP_000119
- 293T whole cell lysate and Raji lysate.
Previously labelled as Factor XI.
Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab97346 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 70 kDa.|
FunctionFactor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Tissue specificityIsoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
Involvement in diseaseDefects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
Sequence similaritiesBelongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain.
modificationsActivated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
- Information by UniProt
- Coagulation factor XI antibody
- Coagulation factor XIa light chain antibody
- F11 antibody
ab97346 has not yet been referenced specifically in any publications.