G 418 sulfate (Geneticin sulfate), Aminoglycoside antibiotic agent (ab144261)

Overview

  • Product name
    G 418 sulfate (Geneticin sulfate), Aminoglycoside antibiotic agent
  • Description
    Aminoglycoside antibiotic agent
  • Biological description
    Aminoglycoside antibiotic agent. Potent Delta7-SMN target sequence inducer. Inhibits amino acid incorporation into proteins. Shows cytotoxic effects. Inhibits the prokaryotic and eukaryotic elongation cycle. Shows antibacterial and antiprotozoal effects in vivo.
  • CAS Number
    108321-42-2
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Ho G  et al. In vitro read-through of phenylalanine hydroxylase (PAH) nonsense mutations using aminoglycosides: a potential therapy for phenylketonuria. J Inherit Metab Dis 36:955-9 (2013). Read more (PubMed: 23532445) »
  • Tobe R  et al. High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin. J Biol Chem 288:14709-15 (2013). Read more (PubMed: 23589299) »
  • Heier CR & DiDonato CJ Translational readthrough by the aminoglycoside geneticin (G418) modulates SMN stability in vitro and improves motor function in SMA mice in vivo. Hum Mol Genet 18:1310-22 (2009). Read more (PubMed: 19150990) »

Customer reviews and Q&As

Question
Answer

The lab confirmed the suitability of ab144261 for cell culture.


Please be aware that the product is not made in a sterile environment, therefore you need to take necessary sterilization measures prior to use.



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