Overview

  • Product name

    G10, STING signaling activator
  • Description

    Indirect activator of stimulator of interferon genes (STING) signaling
  • Alternative names

    • STING Agonist-1
  • Biological description

    G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 µM, respectively). G10 (100 µM) increases phosphorylation of IRF3, which is lost in cells lacking STING.

  • Purity

    > 98%
  • CAS Number

    702662-50-8
  • Chemical structure

    Chemical Structure

Properties

  • Excitation

    253nm
  • Emission

    292nm
  • Chemical name

    4-[(2-Chloro-6-fluorophenyl)methyl]-N-(furan-2-ylmethyl)-3-oxo-1,4-benzothiazine-6-carboxamide

  • Molecular weight

    430.88
  • Molecular formula

    C21H16ClFN2O3S
  • PubChem identifier

    5077622
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term.
  • Solubility overview

    Soluble in DMSO to 100mM and in ethanol to 50 mM.

  • SMILES

    C1C(=O)N(C2=C(S1)C=CC(=C2)C(=O)NCC3=CC=CO3)CC4=C(C=CC=C4Cl)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Sali TM  et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog 11:e1005324 (2015). Read more (PubMed: 26646986) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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