Key features and details
- Rabbit polyclonal to GABA A Receptor alpha 1
- Suitable for: WB, IHC-P
- Reacts with: Zebrafish
- Isotype: IgG
Product nameAnti-GABA A Receptor alpha 1 antibody
See all GABA A Receptor alpha 1 primary antibodies
DescriptionRabbit polyclonal to GABA A Receptor alpha 1
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Zebrafish
Recombinant fragment within Zebrafish GABA A Receptor alpha 1 aa 2-281. The exact sequence is proprietary.
Database link: 768183
- Zebrafish brain whole cell lysate
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab211131 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 50 kDa.|
|IHC-P||1/100 - 1/1000.
Suggested antigen retrieval 1mM EDTA-NaOH (pH8.0) 95°C for 1 Hour.
FunctionGABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Involvement in diseaseDefects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4) [MIM:611136]. A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood.
Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5) [MIM:611136]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
- Information by UniProt
- Entrez Gene: 768183 Zebrafish
- ECA4 antibody
- EIEE19 antibody
- EJM antibody
ab211131 has not yet been referenced specifically in any publications.