Anti-GABA A Receptor alpha 1 antibody (ab211131)

Rabbit polyclonal GABA A Receptor alpha 1 antibody. Validated in WB, IHC and tested in Zebrafish. Immunogen corresponding to recombinant fragment.

Overview

  • Product name

    Anti-GABA A Receptor alpha 1 antibody
    See all GABA A Receptor alpha 1 primary antibodies
  • Description

    Rabbit polyclonal to GABA A Receptor alpha 1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Zebrafish
  • Immunogen

    Recombinant fragment within Zebrafish GABA A Receptor alpha 1 aa 2-281. The exact sequence is proprietary.
    Database link: 768183

  • Positive control

    • Zebrafish brain whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab211131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 50 kDa.
IHC-P 1/100 - 1/1000.

Suggested antigen retrieval 1mM EDTA-NaOH (pH8.0) 95°C for 1 Hour.

Target

  • Function

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • Involvement in disease

    Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4) [MIM:611136]. A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood.
    Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5) [MIM:611136]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
  • Sequence similarities

    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
  • Cellular localization

    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ECA4 antibody
    • EIEE19 antibody
    • EJM antibody
    • EJM5 antibody
    • Gaba receptor alpha 1 polypeptide antibody
    • GABA(A) receptor antibody
    • GABA(A) receptor subunit alpha 1 antibody
    • GABA(A) receptor subunit alpha-1 antibody
    • GABA(A) receptor, alpha 1 antibody
    • GABRA 1 antibody
    • GABRA1 antibody
    • Gamma aminobutyric acid (GABA) A receptor alpha 1 antibody
    • Gamma aminobutyric acid A receptor alpha 1 antibody
    • Gamma aminobutyric acid receptor subunit alpha 1 antibody
    • Gamma aminobutyric acid type A receptor alpha1 subunit antibody
    • Gamma-aminobutyric acid receptor subunit alpha-1 antibody
    • GBRA1_HUMAN antibody
    see all

Images

  • Paraffin embedded zebrafish tissue stained for GABA A with ab211131 (1/300) in Immunohistochemical analysis.

  • Anti-GABA A Receptor alpha 1 antibody (ab211131) at 1/1000 dilution + Zebrafish brain whole cell lysate at 30 µg

    Predicted band size: 50 kDa



    10% SDS-PAGE

References

ab211131 has not yet been referenced specifically in any publications.

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