Key features and details
- Rabbit polyclonal to GABA A Receptor alpha 1
- Suitable for: WB
- Reacts with: Rat, Cow, Human
- Isotype: IgG
Product nameAnti-GABA A Receptor alpha 1 antibody
See all GABA A Receptor alpha 1 primary antibodies
DescriptionRabbit polyclonal to GABA A Receptor alpha 1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Rat, Cow, Human
Fusion protein from the cytoplasmic loop of the alpha1-subunit of rat GABAA Receptor
- Rat, bovine, human and mouse brain extracts
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.50
Constituents: 0.238% HEPES, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.01% BSA
Concentration information loading...
PurityImmunogen affinity purified
Purification notesAffinity purified
Our Abpromise guarantee covers the use of ab32589 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).|
FunctionGABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Involvement in diseaseDefects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4) [MIM:611136]. A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood.
Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5) [MIM:611136]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
- Information by UniProt
- ECA4 antibody
- EIEE19 antibody
- EJM antibody
ab32589 has been referenced in 1 publication.
- Gao M et al. Rebound potentiation of inhibition in juvenile visual cortex requires vision-induced BDNF expression. J Neurosci 34:10770-9 (2014). PubMed: 25100608