Anti-GABA A Receptor alpha 3/GABRA3 antibody (ab72446)
Key features and details
- Rabbit polyclonal to GABA A Receptor alpha 3/GABRA3
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
Overview
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Product name
Anti-GABA A Receptor alpha 3/GABRA3 antibody
See all GABA A Receptor alpha 3/GABRA3 primary antibodies -
Description
Rabbit polyclonal to GABA A Receptor alpha 3/GABRA3 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat -
Immunogen
Fusion protein corresponding to Rat GABA A Receptor alpha 3/GABRA3 (N terminal).
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General notes
This product was previously labelled as GABA A Receptor alpha 3
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.50
Constituents: 0.238% HEPES, 0.01% BSA, 50% Glycerol, 0.87% Sodium chloride -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab72446 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa). |
Target
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Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. -
Sequence similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily. -
Cellular localization
Cell junction > synapse > postsynaptic cell membrane. Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 14396 Mouse
- Entrez Gene: 24947 Rat
- SwissProt: P26049 Mouse
- SwissProt: P20236 Rat
- Unigene: 102286 Mouse
- Unigene: 447666 Mouse
- Unigene: 10367 Rat
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Alternative names
- GABA A Receptor alpha 3 antibody
- GABA(A) receptor subunit alpha 3 antibody
- GABA(A) receptor subunit alpha-3 antibody
see all
Images
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All lanes : Anti-GABA A Receptor alpha 3/GABRA3 antibody (ab72446) at 1/1000 dilution
Lane 1 : wild type rat brain lysates
Lane 2 : GABA A Receptor alpha 3/GABRA3 knock out rat brain lysates
Predicted band size: 55 kDa
Observed band size: 55 kDa
Protocols
References (3)
ab72446 has been referenced in 3 publications.
- Long M et al. miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer. Mol Cancer 16:167 (2017). PubMed: 29078789
- Kaneko Y et al. Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro. Sci Rep 6:35659 (2016). WB ; Rat . PubMed: 27767042
- Bates RC et al. Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits. Neuroscience 273:52-64 (2014). PubMed: 24836856