Overview

  • Product name
    Anti-GABA A Receptor beta 2 antibody [EPR10517]
    See all GABA A Receptor beta 2 primary antibodies
  • Description
    Rabbit monoclonal [EPR10517] to GABA A Receptor beta 2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human GABA A Receptor beta 2 (UniProt P47870).

  • Positive control
    • HepG2, A549, fetal brain and Human cerebellum lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab156000 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Predicted molecular weight: 59 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function
      GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    • Tissue specificity
      Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
    • Sequence similarities
      Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily.
    • Cellular localization
      Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • GABA antibody
      • GABA(A) receptor beta 2 antibody
      • GABA(A) receptor subunit beta-2 antibody
      • GABA-A receptor, beta-2 polypeptide antibody
      • GABRB2 antibody
      • Gamma aminobutyric acid (GABA) A receptor, beta 2 antibody
      • Gamma aminobutyric acid A receptor beta 2 antibody
      • Gamma-aminobutyric acid receptor subunit beta-2 antibody
      • Gamma-aminobutyric-acid receptor subunit beta-2 antibody
      • GBRB2_HUMAN antibody
      see all

    Images

    • All lanes : Anti-GABA A Receptor beta 2 antibody [EPR10517] (ab156000) at 1/10000 dilution

      Lane 1 : HepG2 cell lysate
      Lane 2 : A549 cell lysate
      Lane 3 : Fetal brain lysate
      Lane 4 : Human cerebellum lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 59 kDa

    References

    This product has been referenced in:
    • Chen M  et al. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. Elife 6:N/A (2017). WB ; Mouse . Read more (PubMed: 28054918) »
    • Pan B  et al. Chronic administration of aripiprazole activates GSK3ß-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats. Sci Rep 6:30040 (2016). WB ; Rat . Read more (PubMed: 27435909) »
    See all 4 Publications for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab156000.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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