Recombinant
RabMAb

Recombinant Anti-GABA A Receptor beta 2/GABRB2 antibody [EPR10517] (ab156000)

Overview

  • Product name

    Anti-GABA A Receptor beta 2/GABRB2 antibody [EPR10517]
    See all GABA A Receptor beta 2/GABRB2 primary antibodies
  • Description

    Rabbit monoclonal [EPR10517] to GABA A Receptor beta 2/GABRB2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    corresponding to Human GABA A Receptor beta 2/GABRB2.

  • Positive control

    • HepG2, A549, fetal brain and Human cerebellum lysates.
  • General notes

     This product was previously labelled as GABA A Receptor beta 2

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab156000 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Predicted molecular weight: 59 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    • Tissue specificity

      Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
    • Sequence similarities

      Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily.
    • Cellular localization

      Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • GABA antibody
      • GABA(A) receptor beta 2 antibody
      • GABA(A) receptor subunit beta-2 antibody
      • GABA-A receptor, beta-2 polypeptide antibody
      • GABRB2 antibody
      • Gamma aminobutyric acid (GABA) A receptor, beta 2 antibody
      • Gamma aminobutyric acid A receptor beta 2 antibody
      • Gamma-aminobutyric acid receptor subunit beta-2 antibody
      • Gamma-aminobutyric-acid receptor subunit beta-2 antibody
      • GBRB2_HUMAN antibody
      see all

    Images

    • All lanes : Anti-GABA A Receptor beta 2/GABRB2 antibody [EPR10517] (ab156000) at 1/10000 dilution

      Lane 1 : HepG2 cell lysate
      Lane 2 : A549 cell lysate
      Lane 3 : Fetal brain lysate
      Lane 4 : Human cerebellum lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 59 kDa

    References

    This product has been referenced in:

    • Chen M  et al. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. Elife 6:N/A (2017). WB ; Mouse . Read more (PubMed: 28054918) »
    • Pan B  et al. Chronic administration of aripiprazole activates GSK3ß-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats. Sci Rep 6:30040 (2016). WB ; Rat . Read more (PubMed: 27435909) »
    See all 4 Publications for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab156000.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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