Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR10517] to GABA A Receptor beta 2/GABRB2
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Product nameAnti-GABA A Receptor beta 2/GABRB2 antibody [EPR10517]
See all GABA A Receptor beta 2/GABRB2 primary antibodies
DescriptionRabbit monoclonal [EPR10517] to GABA A Receptor beta 2/GABRB2
Tested applicationsSuitable for: WBmore details
Unsuitable for: Flow Cyt,ICC,IHC-P or IP
Species reactivityReacts with: Mouse, Rat, Human
corresponding to Human GABA A Receptor beta 2/GABRB2.
- HepG2, A549, fetal brain and Human cerebellum lysates.
This product was previously labelled as GABA A Receptor beta 2
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferPreservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol, 0.5% BSA
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab156000 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/10000 - 1/50000. Predicted molecular weight: 59 kDa.|
FunctionGABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Tissue specificityIsoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily.
Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
- Information by UniProt
- GABA antibody
- GABA(A) receptor beta 2 antibody
- GABA(A) receptor subunit beta-2 antibody
All lanes : Anti-GABA A Receptor beta 2/GABRB2 antibody [EPR10517] (ab156000) at 1/10000 dilution
Lane 1 : HepG2 cell lysate
Lane 2 : A549 cell lysate
Lane 3 : Fetal brain lysate
Lane 4 : Human cerebellum lysate
Lysates/proteins at 10 µg per lane.
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 59 kDa
ab156000 has been referenced in 7 publications.
- Speigel IA et al. Chronic Calcineurin Inhibition via Cyclosporine A Impairs Visuospatial Learning After Isoflurane Anesthesia. Anesth Analg 129:192-203 (2019). PubMed: 31082969
- Zhang K et al. CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice. J Clin Invest 129:2333-2350 (2019). PubMed: 31063987
- Andrés-Benito P et al. Gene Expression Profile in Frontal Cortex in Sporadic Frontotemporal Lobar Degeneration-TDP. J Neuropathol Exp Neurol 77:608-627 (2018). PubMed: 29788265
- Chen M et al. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. Elife 6:N/A (2017). WB ; Mouse . PubMed: 28054918
- Pan B et al. Chronic administration of aripiprazole activates GSK3ß-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats. Sci Rep 6:30040 (2016). WB ; Rat . PubMed: 27435909
- Tjomsland V et al. Profile of MMP and TIMP Expression in Human Pancreatic Stellate Cells: Regulation by IL-1a and TGFß and Implications for Migration of Pancreatic Cancer Cells. Neoplasia 18:447-56 (2016). IHC-P ; Human . PubMed: 27435927
- Kaneko Y et al. Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro. Sci Rep 6:35659 (2016). WB ; Rat . PubMed: 27767042