Key features and details
- Rabbit polyclonal to GABA A Receptor beta 3/GABRB3
- Suitable for: WB, IHC-P, IHC-Fr
- Reacts with: Human
- Isotype: IgG
Product nameAnti-GABA A Receptor beta 3/GABRB3 antibody
See all GABA A Receptor beta 3/GABRB3 primary antibodies
DescriptionRabbit polyclonal to GABA A Receptor beta 3/GABRB3
Tested applicationsSuitable for: WB, IHC-P, IHC-Frmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide corresponding to Human GABA A Receptor beta 3/GABRB3 (N terminal).
We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 23rd June 2017. The following lots are still unpurified and still in stock as of 23rd June 2017 - GR325257-1, GR325257-2, GR325257-3, GR325257-4, GR325257-5, GR325257-6, GR1530-9, GR1530-10. Lot numbers other than GR325257-1, GR325257-2, GR325257-3, GR325257-4, GR325257-5, GR325257-6, GR1530-9, GR1530-10 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.
This product was previously labelled as GABA A Receptor beta 3
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Storage bufferConstituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab66430 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/5000. Predicted molecular weight: 54 kDa.|
|IHC-P||1/100 - 1/500.|
|IHC-Fr||1/100 - 1/500.|
FunctionComponent of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Involvement in diseaseEpilepsy, childhood absence 5
Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily.
Cellular localizationCell junction, synapse, postsynaptic cell membrane. Cell membrane.
- Information by UniProt
- ECA5 antibody
- GABA alpha receptor beta-2 subunit antibody
- GABA(A) receptor subunit beta-3 antibody
ab66430 has been referenced in 1 publication.
- Desrues L et al. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. PLoS One 7:e36319 (2012). ELISA, Flow Cyt ; Human . PubMed: 22563490