GABA and Glutamate Antagonists Kit (ab120376)

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Overview

  • Product name

    GABA and Glutamate Antagonists Kit
    See all Metabotropic glutamate receptor kits

  • Specificity

    A collection of 5 antagonists for Glutamate and GABA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM, respectively. The kit contains LY 341495 sodium salt (ab120400), D-AP5 (ab120003), NBQX disodium salt (ab120046), (-)-Bicuculline methochloride (ab120110) and CGP 52432 (ab120330).

  • Product overview

    A collection of 5 antagonists for Glutamate and GABA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM respectively. The kit contains LY 341495 sodium salt (ab120400), D-AP5 (ab120003), NBQX disodium salt (ab120046), (-)-Bicuculline methochloride (ab120110) and CGP 52432 (ab120330).   

    Receptor description 

    All mGlu (mGlu1,2,3,4,5,6,7,8) 

    LY 341495 sodium salt: Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values are 1.67, 0.75, 31.6, 72.7, 14 nM at human mGlu2, mGlu3, mGlu6, mGlu7a, and human mGlu8a receptors respectively. IC50 values are 7.8, 8.2 and 22 µM for mGlu1a, mGlu5a and mGlu4 receptors. Readily brain penetrant and active in vivo. Suggested Solvent: Water  

    NMDA 

    D-AP5: Competitive NMDA receptor glutamate site antagonist. More active form of DL-AP5. Suggested Solvent: Water  

    AMPA/Kainate 

    NBQX disodium salt: Water soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo. Suggested Solvent: Water 

    GABAA 

     (-)-Bicuculline methochloride: Water-soluble GABAA antagonist. Methochloride salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported. Suggested Solvent: Water  

    GABAB 

    CGP 52432: Potent, selective GABAB antagonist (IC50 = 85 nM). Suggested Solvent: Water

  • Notes

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Properties

References

ab120376 has not yet been referenced specifically in any publications.

Publishing research using ab120376? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

Customer kindly asked how they can solublize the product in the kits.

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Answer

Thank you for contacting us.

These products are freeze dried to an exact weight so adding 0.5 ml in each product will give you conc. of 10 mM.

0.5 ml addition of water or solvent into each product will give 10 mM solution.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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