Key features and details
- Chicken polyclonal to GABA
- Suitable for: ICC
- Reacts with: Species independent
- Isotype: IgY
Product nameAnti-GABA antibody
See all GABA primary antibodies
DescriptionChicken polyclonal to GABA
SpecificityFixed tissue cross-reactivity tested with known targets at recommended dilution. No measurable glutaraldehyde-fixed tissue cross-reactivity (<1:1000) against: L-alanine, D/L-aspartate, agmatine, D/L-arginine, L-citrulline, L-cysteine, D/L-glutamate, D/L-glutamine, glutathione, glycine, L-histidine, L-isoleucine, L-lysine, L-leucine, L-methionine, L-asparagine, L-ornithine, L-proline, L-serine, taurine, L-threonine, L-valine, L-tryptophan, L-tyrosine. No measurable reactivity against formaldehyde fixed proteins
Tested applicationsSuitable for: ICCmore details
Species reactivityReacts with: Species independent
Full length native protein (purified) corresponding to Cow GABA (Glutaraldehyde). 4-aminobutyrate cross-linked to purifed fraction V bovine serum albumin with glutaraldehyde.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Thimerosal (merthiolate)
Constituent: 0.268% PBS
Concentration information loading...
Purification notesIgYs were separated from other yolk proteins by serial PEG6000 extractions using a modification of the method of Polsonet al Immunological Investigations.
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab62669 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceGamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABA acts at inhibitory synapses in the brain and spinal cord. Inhibition is provoked by GABA binding resulting in hyperpolarization of the synaptic transmembrane potential of the affected neuron. GABA binding causes ion channels to open allowing either the flow of chloride or potassium ions into or out of the cell.
Cellular localizationCell Membrane, Cytoplasmic, Plasma membrane and Secreted
- 4 aminobutanoic acid antibody
- GABA antibody
- Gamma amino butyric acid antibody
- Gamma aminobutyric acid antibody
ab62669 has been referenced in 2 publications.
- Ausborn J et al. Organization of the core respiratory network: Insights from optogenetic and modeling studies. PLoS Comput Biol 14:e1006148 (2018). PubMed: 29698394
- Estakhr J et al. Differential Control of Dopaminergic Excitability and Locomotion by Cholinergic Inputs in Mouse Substantia Nigra. Curr Biol 27:1900-1914.e4 (2017). PubMed: 28648825