• Product name
    Anti-GABA B Receptor 2 antibody
    See all GABA B Receptor 2 primary antibodies
  • Description
    Rabbit polyclonal to GABA B Receptor 2
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 761-810 (


    ) of Human GABBR2 (NP_005449).

  • Positive control
    • HeLa cell lysate



Our Abpromise guarantee covers the use of ab115929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 106 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
  • Tissue specificity
    Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
  • Domain
    Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
  • Cellular localization
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BcDNA:GH07312 antibody
    • CG6706 antibody
    • CT20836 antibody
    • D Gaba2 antibody
    • FLJ36928 antibody
    • G protein coupled receptor 51 antibody
    • G-protein coupled receptor 51 antibody
    • GAB B R2 antibody
    • GABA B R2 antibody
    • GABA B receptor 2 antibody
    • GABA-B receptor 2 antibody
    • GABA-B-R2 antibody
    • GABA-BR2 antibody
    • GABAB R2 antibody
    • GABABR 2 antibody
    • GABABR2 antibody
    • GABB R2 antibody
    • GABBR 2 antibody
    • Gabbr2 antibody
    • GABR2_HUMAN antibody
    • Gamma aminobutyric acid B receptor 2 antibody
    • Gamma aminobutyric acid GABA B receptor 2 antibody
    • Gamma aminobutyric acid type B receptor subunit 2 antibody
    • Gamma-aminobutyric acid type B receptor subunit 2 antibody
    • Gb 2 antibody
    • Gb2 antibody
    • GH07312 antibody
    • GPR 51 antibody
    • GPR51 antibody
    • GPRC 3B antibody
    • GPRC3B antibody
    • HG 20 antibody
    • HG20 antibody
    • HRIHFB2099 antibody
    • Metabotropic GABA B receptor subtype 2 antibody
    • OTTHUMP00000021776 antibody
    • OTTHUMP00000063797 antibody
    • R2 SUBUNIT antibody
    see all


  • Anti-GABA B Receptor 2 antibody (ab115929) at 1 µg/ml + HeLa cell lysate at 10 µg

    Predicted band size: 106 kDa

    Gel concentration: 6-18%


ab115929 has not yet been referenced specifically in any publications.

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