• Product name
    Anti-GABA B Receptor 2 antibody
    See all GABA B Receptor 2 primary antibodies
  • Description
    Rabbit polyclonal to GABA B Receptor 2
  • Host species
  • Specificity
    ab52248 detects endogenous levels of total GABA B Receptor 2 protein.
  • Tested applications
    Suitable for: IHC-FoFr, IHC (PFA fixed), WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide derived from human GABA B receptor.

  • Positive control
    • HeLa cells.



Our Abpromise guarantee covers the use of ab52248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FoFr Use at an assay dependent concentration.
IHC (PFA fixed) 1/300.
WB 1/300 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
ELISA 1/10000.


  • Function
    Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
  • Tissue specificity
    Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
  • Domain
    Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
  • Cellular localization
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BcDNA:GH07312 antibody
    • CG6706 antibody
    • CT20836 antibody
    • D Gaba2 antibody
    • FLJ36928 antibody
    • G protein coupled receptor 51 antibody
    • G-protein coupled receptor 51 antibody
    • GAB B R2 antibody
    • GABA B R2 antibody
    • GABA B receptor 2 antibody
    • GABA-B receptor 2 antibody
    • GABA-B-R2 antibody
    • GABA-BR2 antibody
    • GABAB R2 antibody
    • GABABR 2 antibody
    • GABABR2 antibody
    • GABB R2 antibody
    • GABBR 2 antibody
    • Gabbr2 antibody
    • GABR2_HUMAN antibody
    • Gamma aminobutyric acid B receptor 2 antibody
    • Gamma aminobutyric acid GABA B receptor 2 antibody
    • Gamma aminobutyric acid type B receptor subunit 2 antibody
    • Gamma-aminobutyric acid type B receptor subunit 2 antibody
    • Gb 2 antibody
    • Gb2 antibody
    • GH07312 antibody
    • GPR 51 antibody
    • GPR51 antibody
    • GPRC 3B antibody
    • GPRC3B antibody
    • HG 20 antibody
    • HG20 antibody
    • HRIHFB2099 antibody
    • Metabotropic GABA B receptor subtype 2 antibody
    • OTTHUMP00000021776 antibody
    • OTTHUMP00000063797 antibody
    • R2 SUBUNIT antibody
    see all


  • All lanes : Anti-GABA B Receptor 2 antibody (ab52248) at 1/300 dilution

    Lane 1 : HeLa cell extract; without peptide
    Lane 2 : HeLa cell extract; with peptide

    Predicted band size: 106 kDa
    Observed band size: 106 kDa

  • Immunohistochemistical detection of GABA B Receptor 2 antibody (ab52248) in PFA fixed Rat Dorsal root ganglion sections. ab52248 was used at 1/300 and incubated for 60 hours @ 4°C in PBS-T 0.3%. Secondary antibody: anti IgG Rabbit Conjugation: Alexa Fluor® 488 (1/1000).


This product has been referenced in:
  • Li Y  et al. Validation and bioinformatic analysis of propofol-induced differentially expressed microRNAs in primary cultured neural stem cells. Gene 664:90-100 (2018). WB . Read more (PubMed: 29679758) »
  • Thibault K  et al. Molecular mechanisms underlying the enhanced analgesic effect of oxycodone compared to morphine in chemotherapy-induced neuropathic pain. PLoS One 9:e91297 (2014). WB, IHC-Fr, IHC-FrFl ; Rat . Read more (PubMed: 24618941) »
See all 2 Publications for this product

Customer reviews and Q&As

Abcam guarantees this product to work in the species/application used in this Abreview.
Immunohistochemistry (PFA perfusion fixed frozen sections)
Rat Tissue sections (Dorsal root ganglion)
Dorsal root ganglion

Dr. Karine Thibault

Verified customer

Submitted Oct 13 2010


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