Key features and details
- Rabbit polyclonal to GABA B Receptor 2/GABBR2 (phospho S783)
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Product nameAnti-GABA B Receptor 2/GABBR2 (phospho S783) antibody
See all GABA B Receptor 2/GABBR2 primary antibodies
DescriptionRabbit polyclonal to GABA B Receptor 2/GABBR2 (phospho S783)
ab72447 recognises GABA B Receptor 2/GABBR2 when phosphorylated at Ser 783.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Rat
Predicted to work with: Mouse, Chicken, Cow, Human, Xenopus laevis, Non human primates
Synthetic peptide corresponding to Rat GABA B Receptor 2/GABBR2.
- rat synaptic membrane
This product was previously labelled as GABA B Receptor 2
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.50
Constituents: 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab72447 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).|
FunctionReceptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Tissue specificityHighly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
Sequence similaritiesBelongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
DomainAlpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
Cellular localizationCell membrane. Cell junction > synapse > postsynaptic cell membrane. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
- Information by UniProt
- BcDNA:GH07312 antibody
- CG6706 antibody
- CT20836 antibody
All lanes : Anti-GABA B Receptor 2/GABBR2 (phospho S783) antibody (ab72447) at 1/1000 dilution
Lane 1 : rat synaptic membrane
Lane 2 : rat synaptic membrane pre-incubated in lambda-Phosphatase (1200 units
for 30 min)
Predicted band size: 106 kDa
Observed band size: 106 kDa
The immunolabeling is completely eliminated by treatment with lambda Ptase.
ab72447 has not yet been referenced specifically in any publications.