Overview

  • Product name

    Gabexate mesylate, General serine protease inhibitor
  • Description

    General serine protease inhibitor
  • Alternative names

    • FOY
  • Biological description

    General serine protease inhibitor (Ki values are 3.4 nM, 5, 1.8 µM and 2.6 mM at tryptase, thrombin, tyrpsin and kallikrein serine proteases respectively). Additionally inhibits nitric oxide synthase. Displays antithrombotic activity and antitumor effect. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    56974-61-9
  • Chemical structure

    Chemical Structure

Properties

Associated products

References

This product has been referenced in:

  • Aki T  et al. Protective effects of amino acids against gabexate mesilate-induced cell injury in porcine aorta endothelial cells. J Pharmacol Sci 107:238-45 (2008). Read more (PubMed: 18587221) »
  • Yuksel M  et al. Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes. J Pharmacol Exp Ther 305:298-305 (2003). Read more (PubMed: 12649382) »
  • Erba F  et al. Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug. Biochem Pharmacol 61:271-6 (2001). Read more (PubMed: 11172730) »

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