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Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist (ab120426)

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Chemical Structure - Gaboxadol hydrochloride (THIP hydrochloride), GABA<sub>A</sub> receptor agonist and GABA<sub>C</sub> receptor antagonist (ab120426)

    Key features and details

    • GABAA receptor agonist and GABAC receptor antagonist
    • CAS Number: 64603-91-4
    • Purity: > 98%
    • Soluble in water to 100 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist
    • Description

      GABAA receptor agonist and GABAC receptor antagonist
    • Biological description

      GABAA receptor agonist and GABAC receptor antagonist. Antinociceptive, anticonvulsant and hypnotic agent. Blood-brain barrier permeable. Active in vivo and in vitro.
    • Purity

      > 98%
    • CAS Number

      64603-91-4
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
    • Molecular weight

      176.60
    • Molecular formula

      C6H8N2O2HCl
    • PubChem identifier

      5702253
    • Storage instructions

      Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM and in DMSO to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      C1CNCC2=C1C(=O)NO2.Cl
    • Source

      Synthetic

    • Research areas

      • Biochemicals
      • Product Range
      • New
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
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      • Receptors & Transporters
      • GABA
      • Other
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • GABA
      • GABAA
      • Agonists

    Images

    • Chemical Structure - Gaboxadol hydrochloride (THIP hydrochloride), GABA<sub>A</sub> receptor agonist and GABA<sub>C</sub> receptor antagonist (ab120426)
      Chemical Structure - Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist (ab120426)
      2D chemical structure image of ab120426, Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (2)

    Publishing research using ab120426? Please let us know so that we can cite the reference in this datasheet.

    ab120426 has been referenced in 2 publications.

    • Rudolph S  et al. Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior. Cell Rep 33:108338 (2020). PubMed: 33147470
    • Luo R  et al. Distinct roles of synaptic and extrasynaptic GABAAreceptors in striatal inhibition dynamics. Front Neural Circuits 7:186 (2013). PubMed: 24324406

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