Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist (ab120426)
- Datasheet
- References (1)
Overview
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Product name
Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist -
Description
GABAA receptor agonist and GABAC receptor antagonist -
Biological description
GABAA receptor agonist and GABAC receptor antagonist. Antinociceptive, anticonvulsant and hypnotic agent. Blood-brain barrier permeable. Active in vivo and in vitro. -
Purity
> 98% -
CAS Number
64603-91-4 -
Chemical structure
Properties
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Chemical name
4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride -
Molecular weight
176.60 -
Molecular formula
C6H8N2O2HCl -
PubChem identifier
5702253 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CNCC2=C1C(=O)NO2.Cl -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Morishita W & Sastry BR Postsynaptic mechanisms underlying long-term depression of GABAergic transmission in neurons of the deep cerebellar nuclei. J Neurophysiol 76:59-68 (1996). Read more (PubMed: 8836209) »
- Johnston GA GABAc receptors: relatively simple transmitter -gated ion channels? Trends Pharmacol Sci 17:319-23 (1996). Read more (PubMed: 8885697) »
- Krogsgaard-Larsen P et al. 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J Med Chem 26:895-900 (1983). Read more (PubMed: 6304315) »
