Key features and details
- GABAA receptor agonist and GABAC receptor antagonist
- CAS Number: 64603-91-4
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameGaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist
DescriptionGABAA receptor agonist and GABAC receptor antagonist
Biological descriptionGABAA receptor agonist and GABAC receptor antagonist. Antinociceptive, anticonvulsant and hypnotic agent. Blood-brain barrier permeable. Active in vivo and in vitro.
Chemical name4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120426 has been referenced in 2 publications.
- Rudolph S et al. Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior. Cell Rep 33:108338 (2020). PubMed: 33147470
- Luo R et al. Distinct roles of synaptic and extrasynaptic GABAAreceptors in striatal inhibition dynamics. Front Neural Circuits 7:186 (2013). PubMed: 24324406