Overview

  • Product name

  • Description

    Rabbit polyclonal to GABRB1
  • Host species

    Rabbit
  • Specificity

    Reacts with the 51-54 kDa beta 1 subunit of rat brain GABA A. There is no homology or known reactivity with other GABA subunits.
  • Tested applications

    Suitable for: IHC-P, WB, IPmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Rat GABRB1.

  • Positive control

    • rat forebrain lysate, rat cerebellum or cortex lysate
  • General notes

     This product was previously labelled as GABA A Receptor beta 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab16703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration. PubMed: 18539546
WB 1/1000. Predicted molecular weight: 53 kDa.
IP Use at an assay dependent concentration. Use at an assay dependent dilution. 15 ug of antibody were used to IP 24% of all GABA-A receptors in dodecylsulfate extracts of rat forebrains (150 ul).

Target

  • Function

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • Sequence similarities

    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily.
  • Cellular localization

    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • AW061132 antibody
    • B230208N19Rik antibody
    • GABA(A) receptor beta 1 antibody
    • GABA(A) receptor subunit beta-1 antibody
    • GABA-A receptor, beta-1 polypeptide antibody
    • Gabrb-1 antibody
    • GABRB1 antibody
    • Gamma aminobutyric acid (GABA) A receptor beta 1 antibody
    • Gamma Aminobutyric Acid A Receptor Beta 1 antibody
    • Gamma Aminobutyric Acid Receptor , beta-1 antibody
    • Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 antibody
    • Gamma-aminobutyric acid receptor subunit beta-1 antibody
    • GARB1 antibody
    • GBRB1_HUMAN antibody
    see all

Images

References

This product has been referenced in:

  • Quintana A  et al. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nat Neurosci 15:1547-55 (2012). Mouse . Read more (PubMed: 23064379) »
  • Adusei DC  et al. Early developmental alterations in GABAergic protein expression in fragile X knockout mice. Neuropharmacology 59:167-71 (2010). WB ; Mouse . Read more (PubMed: 20470805) »
See all 3 Publications for this product

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