Overview

  • Product name

  • Description

    Rabbit polyclonal to GABRR1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cat, Dog
  • Immunogen

    Synthetic peptide to a region within N terminal amino acids 36-85 (MSKKGRPQRQ RREVHEDAHK QVSPILRRSP DITKSPLTKS EQLLRIDDHD) of Human GABRR1 (NP_002033)

  • Positive control

    • Hela cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab85667 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 56 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
  • Tissue specificity

    Highly expressed in the retina and in a lesser extent in brain, lung and thymus.
  • Sequence similarities

    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily.
  • Cellular localization

    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • bA135P14.1 (gamma-aminobutyric acid (GABA) receptor rho 1) antibody
    • GABA(A) receptor subunit rho-1 antibody
    • GABA(C) receptor antibody
    • GABRR1 antibody
    • gamma aminobutyric acid receptor rho 1 antibody
    • gamma-aminobutyric acid (GABA) A receptor rho-1 antibody
    • gamma-aminobutyric acid (GABA) receptor rho 1 antibody
    • Gamma-aminobutyric acid receptor subunit rho-1 antibody
    • GBRR1_HUMAN antibody
    • MGC163216 antibody
    see all

Images

  • Anti-GABRR1 antibody (ab85667) at 1 µg/ml (in 5% skim milk / PBS buffer) + Hela cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size: 56 kDa
    Observed band size: 56 kDa
    Additional bands at: >90 kDa. We are unsure as to the identity of these extra bands.



    Gel concentration 12%

References

This product has been referenced in:

  • Hannan S & Smart TG Cell surface expression of homomeric GABAA receptors depends on single residues in subunit transmembrane domains. J Biol Chem 293:13427-13439 (2018). Read more (PubMed: 29986886) »
See 1 Publication for this product

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